Today we introduce the major players in the building conflict. We talk about Charles V & Suleiman the Magnificent. We talk about Khizr Barbarossa and his Italian raids that culminated in one of Renaissance Italy’s greatest tales. We discuss Sinan Reis, who the Portuguese called ‘The Great Jew’ and his personal war on Spanish shipping that brought Mediterranean trade to a virtual halt. And then we introduce the last major player. Andrea Doria, a Genoese mercenary who turned down a crown to continue his fight against the Corsairs of Barbary.